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    Friedreich's footprint
      Nikolaus Friedreich (1825-1882) was a German neurologist, who is probably best remembered for giving his name to the rare progressive autosomal neurodegenerative disease Friedreich's ataxia, but he was also interested in several other branches of medicine. He was instrumental in the establishment o ....more | Save |  Share  Email 1st Feb 2015 
    Brain banking as a cornerstone of neuroscience in China
      Studies of the human brain have played a vital part in the advancement of modern neuroscience. Microscopic and histological inventions used by Camillo Golgi, Santiago Ramón y Cajal, and others to study human brain tissue contributed to the formulation of the reticular theory and neuron doctrine, w ....more | Save |  Share  Email 1st Feb 2015 
    Orbital compartment syndrome after head trauma
      Rachel Ventura and colleagues1 have identified a gap in the scientific literature in their recent Review of the neuro-ophthalmology of head trauma. Traumatic brain injury is a challenging area of clinical medicine. The usefulness and promise of neuro-ophthalmological assessment as a screening metho ....more | Save |  Share  Email 1st Feb 2015 
    Putting palliative care on the global health agenda
      Palliative care-defined by WHO as "an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering?1-has been largely absent from the global health dialogue and consequently a ....more | Save |  Share  Email 1st Feb 2015 
    Building a global consensus approach to chordoma: a position paper from the medical and patient community
      Chordomas are very rare bone malignant tumours that have had a shortage of effective treatments for a long time. New treatments are now available for both the local and the metastatic phase of the disease, but the degree of uncertainty in selecting the most appropriate treatment remains high and th ....more | Save |  Share  Email 1st Feb 2015 
    Regenerative medicine for oesophageal reconstruction after cancer treatment
      Removal of malignant tissue in patients with oesophageal cancer and replacement with autologous grafts from the stomach and colon can lead to problems. The need to reduce stenosis and anastomotic leakage after oesophagectomy is a high priority. Developments in tissue-engineering methods and cell-sh ....more | Save |  Share  Email 1st Feb 2015 
    Overcoming barriers in progressive multiple sclerosis research
      The past two decades have seen a profound change in the treatment of multiple sclerosis. With recent regulatory approvals, 12 disease-modifying treatments are available in many countries for relapsing-remitting multiple sclerosis (RRMS) and there is a robust pipeline of experimental treatments at v ....more | Save |  Share  Email 1st Feb 2015 
    Prostate cancer: a practical guide
      What Men Won't Talk About...and Women Need to Know: A Woman's Perspective on Prostate Cancer by Glenda Standeven is a practical book, designed with a specific purpose-to help women whose husbands have prostate cancer. The slim book is written in an engaging, conversational style as if Standeven is ....more | Save |  Share  Email 1st Feb 2015 
    Radiotherapy or surgery for the axilla in node-positive breast cancer?
      The benefits of adjuvant radiotherapy in positive axillary nodal regions after breast-conserving and postmastectomy surgery have been recently demonstrated.1,2 Even though sentinel lymph node biopsy has largely replaced lymphadenectomy in the assessment of micrometastases in sentinel lymph nodes, i ....more | Save |  Share  Email 1st Feb 2015 
    Clinical trials in progressive multiple sclerosis: lessons learned and future perspectives
      Progressive multiple sclerosis is characterised clinically by the gradual accrual of disability independent of relapses and can occur with disease onset (primary progressive) or can be preceded by a relapsing disease course (secondary progressive). An effective disease-modifying treatment for progr ....more | Save |  Share  Email 1st Feb 2015 
    Recalibrating emergency care in the UK
      In January, 2015, the UK National Health Service (NHS) reported a record number of patients using accident and emergency (A&E) departments, which led to several hospitals declaring "major incident? status. This status meant cancelling outpatient services and non-essential surgeries (including can ....more | Save |  Share  Email 1st Feb 2015 
    Towards a global cancer fund
      The annual death toll from cancer has risen by almost 40% since 1990,1 and this increase is set to continue. Deaths from cancer are projected to increase from the present level of around 8 million a year to more than 13 million by 2030, with most of the burden being in poorer countries.2 Once a pro ....more | Save |  Share  Email 1st Feb 2015 
    SUDEP research without walls
      The creation of a virtual Center Without Walls to study sudden unexpected death in epilepsy (SUDEP) was announced by the US National Institute of Neurological Disorders and Stroke (NINDS) on Dec 8, 2014. For the epilepsy community-at that time gathered in Seattle, WA, USA, for the Annual Meeting of ....more | Save |  Share  Email 1st Feb 2015 
    A much-needed focus on progression in multiple sclerosis
      Few neurological disorders have seen so great a transformation in public perception as multiple sclerosis. Over the past 20 years, the disease has moved from being an untreatable disorder with few management options to one with active management underpinned by a wide range of oral and injectable tr ....more | Save |  Share  Email 1st Feb 2015 
    Treatment of progressive multiple sclerosis: what works, what does not, and what is needed
      Disease-modifying drugs have mostly failed as treatments for progressive multiple sclerosis. Management of the disease therefore solely aims to minimise symptoms and, if possible, improve function. The degree to which this approach is based on empirical data derived from studies of progressive dise ....more | Save |  Share  Email 1st Feb 2015 
    Radiotherapy or surgery for the axilla in node-positive breast cancer? - Authors' reply
      We appreciate Lorenzo Livi, Icro Meattini, and Paolo Farace and colleagues' comments on our AMAROS study1 which examined whether axillary radiation therapy can replace axillary lymph node dissection (ALND) and whether axillary structures could be better spared using axillary radiotherapy. ....more | Save |  Share  Email 1st Feb 2015 
    Are we ready for direct-to-consumer genetic testing?
      We'd perhaps best decide, and quick, because it's here. UK citizens can now have their DNA checked cheaply and quickly for disease-associated mutations. But is that a good thing? Adrian Burton investigates. ....more | Save |  Share  Email 1st Feb 2015 
    Familial gastric cancer: genetic susceptibility, pathology, and implications for management
      Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial intestinal gastric cancer. The risk of development of gastric cancer is high in families affected b-y these syndromes, but ....more | Save |  Share  Email 1st Feb 2015 
    The paradox of preoperative (chemo)radiotherapy for rectal cancer
      Clinicians in many countries, as well as international guidelines (NCCN, ASCO, ESMO) recommend adjuvant chemotherapy for stage II-III rectal cancer after preoperative (chemo)radiotherapy, assuming the same benefit in distant recurrences as in colon cancer, but the available data do not unequivocall ....more | Save |  Share  Email 1st Feb 2015 
    Correction to 2015; 16: 87
      Oza AM, Cibula D, Benzaquen AO, et al. Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial. Lancet Oncol 2015; 16: 87-97-In the Summary of this Article (published Online First on Dec 4, 2014), the Interpretation section should have read "O ....more | Save |  Share  Email 1st Feb 2015 
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