Stem Cell Research Trends and Perspectives

Stem Cell Research Trends and Perspectives

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Description: Stem Cell Research , Trends and Perspectives on the Evolving International Landscape.A EuroStemCell, Kyoto University’s Institute for Integrated Cell-Material Sciences (WPI-iCeMS) and Elsevier collaboration. Objectives: Stem cell science may (will) revolutionize the way we treat diseases. Nations are investing in stem cell research and its applications.

To support stem cell science and policy, we combined Elsevier’s research analytics with EuroStemCell, iCeMS and Cell Press insights views, and experts interviews and advises. Studied trends on volume & directions of research, academy-corporate collaborations, and investigated possible relation to policies.If the Research and Higher Education Enterprise is not Healthy, the Science Publication Business will also not be Healthy. Elsevier’s Motivations: Take stock in the progress and value of scientific research, Contribute to the development of stem cell science, Support health and medical sciences.Stem cell science gives hope to treat a wide range of diseases .Great potential to revolutionize healthcare , Embryonic stem cell research is controversial.

International collaboration gives higher citation impact Most active international collaboration: Switzerland, Singapore, Sweden, Denmark, Netherlands. Conclusions: Rapidly growing field of stem cell research , Stem cell publications are highly cited , 50% of the stem cell papers use keywords related to “drug development” or “regenerative medicine” , Singapore, Italy, ...Please navigate Paper pages for more details.

 
Author: Brad Fenwick DVM MS PhD DACVM (Fellow) | Visits: 1187 | Page Views: 1582
Domain:  Medicine Category: Biotech/Pharma Subcategory: Business 
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Contents:
Stem Cell Research
Trends and Perspectives on the Evolving International Landscape
A EuroStemCell, Kyoto University’s Institute for Integrated
Cell-Material Sciences (WPI-iCeMS) and Elsevier collaboration
Brad Fenwick DVM, MS, PhD, DACVM
Professor / Jefferson Science Fellow
Senior Vice President Global Strategic Alliances
ELSEVIER

A Collaboration Between 4 Stakeholders
Objectives:
• Stem cell science may (will) revolutionize the way we treat diseases.
Nations are investing in stem cell research and its applications.
• To support stem cell science and policy, we combined Elsevier’s research
analytics with EuroStemCell, iCeMS and Cell Press insights views, and experts
interviews and advises.
• Studied trends on volume & directions of research, academy-corporate
collaborations, and investigated possible relation to policies.

Elsevier - Privileged vantage point on the global world
of research

Elsevier – From publisher to solution provider

• Founded 130+ years ago
• 7,000 employees in 25 countries
• Serving 30 million+ scientists,
students, health and information
professionals in 180+ countries

• 2,000 journals, 20,000 books,
dozens of research databases

Each year

• 1 million manuscripts
submitted to 2,000+ Elsevier
journals

• 300,000+ articles published
• 700 million digital article
downloads delivered

• 20,000+ journals, 2 million
articles tracked by Scopus

• Terabytes of data: SciVal
Analytics

Scopus data & SciVal Analytics support
national research assessments and policies
UK’s national Research Excellence
Framework assessment program,
2014

Knowledge Networks
and Nations
Royal Society, 2011
The Water and Food
Nexus. Stockholm
International Water
Institute, 2012

National Excellence in Research for
Australia assessment program,
2012

International Comparative
Performance
of UK Research Base, UK
(BIS), 2011

If the Research and Higher Education
Enterprise is not Healthy, the Science
Publication Business will also not be Healthy

Elsevier’s Motivations

• Take stock in the progress and
value of scientific research
• Contribute to the development of
stem cell science
• Support health and medical
sciences

Exciting Science, Complex Issues

• Stem cell science gives hope to treat a wide range of diseases
• Great potential to revolutionize healthcare
• Embryonic stem cell research is controversial

Key Questions

• What is the global publication trend in stem cell science?

1

• How is the growth in research on ES cells and iPS cells?
• Which countries have the largest publication volume and citation impact?

2

• Do different countries focus on different aspects of stem cell research?

• What influence on policy can be seen from volume/direction of stem cell

3

research? What conclusions are drawn by our interviewee experts?

Advisors and Authors
EuroStemCell
MRC Centre for
Regenerative Medicine
University of Edinburgh
WPI-iCeMS
Kyoto University
Cell Press

Emma Kemp
EuroStemCell

Elsevier
Jan Barfoot
EuroStemCell
Deborah Sweet
Cell Press
Clare Blackburn
EuroStemCell

Anders
Karlsson,
Elsevier B.V

Anand Gavai
Elsevier B.V
Norio Nakatsuji
iCeMS, Kyoto University

Emilie Marcus
Cell Press
Shintaro Sengoku,
WPI-iCeMS, Kyoto
University

Alexander van Servellen
Elsevier B.V

9
Kate Doherty
EuroStemCell

Interviewees
ISSCR, Canada
NIH-CRM, USA
Pfizer, USA
Univ. of York, UK
Univ. of Manchester, UK

Andrew Webster
Univ. of York

Lund Univ., Sweden

Goran Hermeren
Lund University

European Commission, EU
Univ. of Milan, Italy
A*STAR, Singapore
CiRA, Kyoto Univ., Japan

Janet Rossant
ISSCR, The Hospital
for Sick Children
Univ. of Toronto

Sarah Chan
Univ. of
Manchester

RIKEN, Japan
NCCHD, Japan

Sandra Engle
Pfizer Inc.

Stem Cells Australia

Charles Kessler
European Commission
Doug Sipp
RIKEN
Elena Cattaneo
University of Milan
Shinya Yamanaka
CiRA - Kyoto University
ISSCR

Mahendra Rao
NIH-CRM

Akihiro Umezawa
National Center for Child
Health & Development

Huck Hui Ng
A*STAR
Martin Pera
Stem Cells Australia
Univ. of Melbourne

10

Among Experts Comments
“I hope society will be tolerant enough to support and
nurture an atmosphere where challenges is welcomed.”
Akihiro Umezawa, NCCHD, Japan

Among Experts Comments
“I hope society will be tolerant enough to support and
nurture an atmosphere where challenges is welcomed.”
Akihiro Umezawa, NCCHD, Japan

“If the development of iPS cells had not occurred you
would not see the explosive growth in stem cell biology,
as it made human stem cells accessible to everyone.”
Sandra Engle, Pfizer, USA

Among Experts Comments
“I hope society will be tolerant enough to support and
nurture an atmosphere where challenges is welcomed.”
Akihiro Umezawa, NCCHD, Japan

“If the development of iPS cells had not occurred you
would not see the explosive growth in stem cell biology,
as it made human stem cells accessible to everyone.”
Sandra Engle, Pfizer, USA

“Ongoing dialogues between different stakeholder groups
on how to address the ethical issues raised by different
therapies is a long term investment which will pay off.”
Goran Hermeren, Lund University, Sweden

Content of the Report
• Introduction to stem cell research
• Focus on promising ES and iPS cells*
• Analysis of the publication landscape
• Study of leading nations’
o research output
o citation impact
o collaboration behavior

• 11 authors & advisors
• 13 experts commentaries
ES cells – Embryonic Stem cells
iPS cells – Induced Pluripotent Stem cells

Key Messages
• Stem cell research grows at 7 % annually, two times faster than world average
• iPS cell research has an annual growth of 77 %
• Half of publications refer to “regenerative medicine” and “drug development”
• USA retains a global lead in all areas of stem cell research
• Japan is above average growth and impact in hES cell, at global top level in iPS
research on institutional level
• Singapore is growing fast in all areas of stem cell science

Some Overall Findings
CAGR 2008-2012

FWCI

7 % Stem Cells
4.9 % Embryonic Stem cells
77 % iPS cells
(2.9 % world average growth)

1.5 Stem cells
1.8 Embryonic stem cells
2.9 iPS cells
times world average in 2012

USA in global lead
Japan pioneer
Singapore fast growing

60 % of international
collaboration for small
EU countries and Singapore

CAGR – Compound Annual Growth Rate
FWCI – Field-Weighted Citation Impact

Stem Cell Research is Growing
Stem cell research publications grew by 7.0% per year between 2008-2012
iPS cell research output grew tremendously to a CAGR* of 77%

CAGR – Compound Annual Growth Rate

Page 21

Stem-cell research areas & growth pattern

iPSC papers show
biggest growth rate
Papers quoting drug
development are
also growing

Page 27

Stem cell research relates to
“Drug Development” or “Regenerative Medicine”?

Analysis using search
terms related to the
themes “regenerative
medicine” and “drug
development”

Almost half of all stem
cell publications were
aligned with one of these
two topics, with most of
the focus devoted to
regenerative medicine

Page 26

Stem cell research relates to
“Drug Development” or “Regenerative Medicine”?

Analysis using search
terms related to the
themes “regenerative
medicine” and “drug
development”

Almost half of all stem
cell publications were
aligned with one of these
two topics, with most of
the focus devoted to
regenerative medicine

Page 26

Which countries are most active?
Notable growth in Iran, India, Brazil, Korea, but yet low impact
High impact in the Netherlands and Switzerland

Page 32

Human Embryonic Stem (hES) Cells:
Country activity and impact
Notable decreases in relative hES cell research activity, most strikingly
in Sweden, but also Denmark, Switzerland, the Netherlands, and the UK

Page 33

Induced Pluripotent Stem (iPS) Cells:
Country activity and impact
High growth rate in research Israel, Switzerland, Denmark and Brazil
Below average growth rate in Japan, USA, Sweden, Singapore and France

Page 33

Relative activity of countries
in Stem Cell Research
Singapore stands out in all areas
Israel in embryonic stem (hES) cells
Japan in induced pluripotent stem (iPS) cells

Page 36

Relative activity of countries
in Stem Cell Research
Singapore stands out in all areas
Israel in embryonic stem (hES) cells
Japan in induced pluripotent stem (iPS) cells

Page 36

Relative activity of countries
in Stem Cell Research
Singapore stands out in all areas
Israel in embryonic stem (hES) cells
Japan in induced pluripotent stem (iPS) cells

Page 36

Relative activity of countries
in Stem Cell Research
Singapore stands out in all areas
Israel in embryonic stem (hES) cells
Japan in induced pluripotent stem (iPS) cells

Page 36

International Collaboration Matters
International collaboration gives higher citation impact
Most active international collaboration: Switzerland,
Singapore, Sweden, Denmark, Netherlands

Page 37-8

Academy – Corporate Collaborations
Singapore, Denmark, Switzerland, stand out in
collaborative papers with industry

Page 39

Policy Connection - USA case

President Barack Obama removes
certain restrictions on federal
funding for research involving new
lines of human ES cells.

A federal judge orders to block all
federally founded stem cell research.
The ban is lifted in 2011.

President George W. Bush passes 2
bills which make it illegal to create,
grow, and abort fetuses for research
purposes.

California provides US$3 billion in
state funds over 10 years to
human ES cell research.
Federal funding is limited to
non-ES and ES cell research
based upon ES cell lines
existing prior to Aug. 9, 2001.

House of Representatives
to loosen the limitation on
federally funded ES cell
research.

Which are the leading institutions worldwide?
Harvard, Stanford and Kyoto Univ. stands out in
ESC Research Institutions with high citation impact

Collaboration Networks
Primary connections are within USA and USA-Europe

Collaboration Networks
Primary Connections are within USA and USA-Europe

Conclusions
• Rapidly growing field of stem cell research
• Stem cell publications are highly cited
• 50% of the stem cell papers use keywords related to
“drug development” or “regenerative medicine”
• Singapore, Italy, USA, Japan, Israel: highest activity levels in stem cell research
• Korea and Singapore: largest increase in relative activity (2008-2012)
• Increasing levels of international collaboration

Download the report at :
http://info.scival.com

Appendices

Key Incentives

SciVal
Publishing
GAR

The report
is based on Scopus,
the engine of SciVal

Provide insights
beyond
journal view

Speaking points
with VITOs

The report
illustrates analytical
capabilities

Support the stem cell
research field

Support policy
development

Identifying the relevant documents in Scopus

• keyword-based
approach to identify
documents
• keywords were
nominated by subject
matter experts

Source: Scopus searches that correspond
to the Solr searches used in this study

Fingerprints of key concepts
in research abstracts
Key concepts were extracted by the Elsevier
Fingerprint Engine, which scans abstracts
from Scopus and extracts meaningful
concepts termed ‘fingerprints’.

Individual Country Focus: Denmark

The report contains
graphs on individual level
which can be added as a
further value story

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