Current approach of the axilla in patients with early-stage breast cancer
The surgical approach of the axilla in patients with early-stage breast cancer has witnessed considerable evolution during the past 25 years. The previously undisputed gold standard of axillary-lymph-node dissection for staging has now been replaced by sentinel-lymph-node biopsy for patients with clinically negative axilla. For selected patients with limited sentinel-lymph-node involvement, completion axillary-lymph-node dissection can be omitted or replaced by axillary radiotherapy, reducing morbidity.
Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic disease in man and great apes. Four species of ebolaviruses have been identified in west or equatorial Africa.
Genetic mismatch of non-HLA haplotypes coding for transmembrane or secreted proteins is associated with an increased risk of functional graft loss independently of HLA incompatibility. As in HLA alloi
The risk of stillbirth is increased in women with intrahepatic cholestasis of pregnancy and singleton pregnancies when serum bile acids concentrations are of 100 ?mol/L or more. Because most women wit
Intrahepatic cholestasis of pregnancy is a complication in 0·2-2% of pregnancies,1 causing pruritis and increased serum bile acids, liver transaminases, and, occasionally, bilirubin. It has been assoc
Pioneering work first identified IgG antibodies binding specifically to donor HLA class l and class ll molecules (donor-specific antibodies) as a major barrier to successful transplantation.1 Antibody
A 19-year-old woman was admitted because she had been behaving strangely and uncharacteristically for the past 6 months. She had also been unstable on her feet and had been noted to have a change in p
Our results suggest that lomustine-temozolomide chemotherapy might improve survival compared with temozolomide standard therapy in patients with newly diagnosed glioblastoma with methylated MGMT promo
Slightly less than 1 h of general anaesthesia in early infancy does not alter neurodevelopmental outcome at age 5 years compared with awake-regional anaesthesia in a predominantly male study populatio
We read with interest the Article by Parekh and colleagues,1 who report non-inferior 24-month progression-free survival following robot-assisted versus open radical cystectomy. Previous investigations
The results of the RAZOR trial (June 23, 2018, p 2525)1 demonstrated that robot-assisted radical cystectomy is a safe and efficacious procedure in comparison with the open approach. The medical commun
Our pooled registry data, which we believe to be more accurate than the case series data, shows that approximately 82% of TKRs last 25 years and 70% of UKRs last 25 years. These findings will be of us
We read with great interest the comments from Larcher and colleagues and Khetrapal and colleagues and appreciate their interest.
Assuming that estimates from national registries are less likely to be biased, patients and surgeons can expect a hip replacement to last 25 years in around 58% of patients.
Encephalitis is a condition of inflammation of the brain parenchyma, occurs as a result of infectious or autoimmune causes, and can lead to encephalopathy, seizures, focal neurological deficits, neuro
Concerns about anaesthesia-related neurological injury in young children have been increasing among parents, health-care providers, and regulatory organisations. These concerns were first prompted by
Although total hip replacement is a successful procedure for many, there is potential for post-operative complications, such as bleeding, wound dehiscence, infection, and dislocation, among others.1-4
Leader in lymphoma research. Born in Le Puy-en-Velay, France, on March 26, 1947, he died of lung cancer in Lyon, France, on Jan 2, 2019, aged 71 years.
The unexpected announcement in the State of the Union address could set the start of a realistic agenda to end HIV/AIDS in the USA, provided funds are secured. Susan Jaffe reports.
While some countries in western Europe celebrate relative successes in the treatment and control of HIV, a burgeoning epidemic in the eastern part of the region poses a continued threat to progress.
We don't expect a smartphone to help us sleep. Screens and connectivity are typically seen as a distraction from sleep. Yet emerging digital technologies are in development that could paradoxically he