Reducing the global burden of depression: a Lancet-World Psychiatric Association Commission
Depression is the leading cause of mental health-related disease burden globally, affecting an estimated 300 million people worldwide.1 It represents a barrier to sustainable development in all regions.2 Depression prevents people from reaching their full potential, impairs human capital, and is associated with premature mortality from suicide and other illnesses.1
Participants' percentage abstinence was significantly higher in both BUP-XR groups than in the placebo group. Treatment with BUP-XR was also well tolerated. The availability of this monthly formulatio
Barbara Haight and colleagues1 report findings from their phase 3 trial, providing evidence that a novel, monthly, long-acting buprenorphine formulation (BUP-XR) is both safe and efficacious in reduci
In their Seminar on alcohol use disorders, Jason Connor and colleagues1 summarise the risk of alcohol consumption to health for the drinker and for whole populations. The authors offer useful advice,
In July, 1965, Medicare, America's landmark national health insurance programme, became law. Today, it covers 55 million people. Susan Jaffe, The Lancet's Washington correspondent, reports.
The case for investing in the health and wellbeing of the largest generation of adolescents in history could be considered self-evident. Failure to do so would counteract hard-won gains from investing
An unprecedented number of humanitarian emergencies of large magnitude and duration is causing the largest number of people in a generation to be forcibly displaced. Yet the existing humanitarian syst
A 42-year-old white man presented to our clinic in October, 2015, with itching in the nasolabial fold and around the eyebrows, with accompaying erythema and desquamation consistent with seborrhoeic de
A 48-year-old woman with a history of sternal chondrosarcoma that had been completely resected 3 years previously presented with a 7-month history of cough and progressive dyspnoea. On admission she h
A 30-year-old man presented to the primary care clinic in June, 2015, with a 3 month history of a painful, foul-smelling mass between the second and third toes of his right foot that had been slowly i
A previously healthy 6-month-old boy presented in September, 2014, with indurated and tender oedema of the left hand, associated with a rapidly spreading purpuric rash on the dorsum. He also had swell
Almost 100 years ago, Gabriela Mistral, Chilean poet and Nobel Prize winner, said that "every law, every freedom or culture movement, has left us for a long time in the shadows; that we always have ar
As a doctor for almost 40 years now, and especially as a geriatrician, I have cared for my share of terminal patients. However, to date I have never had to face a dying medical student. As Sakal's Dea
After 6 years of conflict, the war in Syria is currently the largest humanitarian and refugee crisis. Over 250?000 Syrians have been killed, millions are displaced or living in besieged areas, and 5 m
Like other young graduates of Thai medical schools, Viroj Tangcharoensathien, Senior Advisor of his country's International Health Policy Program (IHPP) and lead author on a Lancet Review about health
The surgical approach of the axilla in patients with early-stage breast cancer has witnessed considerable evolution during the past 25 years. The previously undisputed gold standard of axillary-lymph-
Bleakley T, Smith R, Taylor R. Has the NHS Long Term Plan forgotten we are all going to die? Lancet 2019; 393: 387-89-In this Comment, the seventh sentence of the third paragraph should read: "Further
Women's health care is often treated as all about reproduction. Some "femtech? startups are exploring the innovations that get overlooked as a result.
Ebolaviruses are pathogenic agents associated with a severe, potentially fatal, systemic disease in man and great apes. Four species of ebolaviruses have been identified in west or equatorial Africa.
Genetic mismatch of non-HLA haplotypes coding for transmembrane or secreted proteins is associated with an increased risk of functional graft loss independently of HLA incompatibility. As in HLA alloi
The risk of stillbirth is increased in women with intrahepatic cholestasis of pregnancy and singleton pregnancies when serum bile acids concentrations are of 100 ?mol/L or more. Because most women wit