360 Stem Cell & Regenerative Medicine Newsletter- August 06, 2015

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360 Stem Cell & Regenerative Medicine Newsletter - Aug 06, 2015

Featured Video from CIRM: Role of Stem Cells on Cognitive Dysfunction after Cancer Therapy

“You'd think getting a cancer diagnosis and the subsequent chemo and/or radiation therapy is traumatic enough. But many people receiving cancer therapy also suffer from so-called chemobrain, a condition marked by troubles with memory, attention/concentration, calculations, fine motor skills and other deficits. In this video CIRM grantee and Stanford professor Michelle Monje describes how damage to brain stem cells plays a significance role in this disorder but may also provide new strategies to halt or repair cognitive functions.”

World Stem Cell Summit

PHYS.ORG: NYSCF Global Stem Cell Array Brings Precision Medicine One Step Closer to the Clinic
“Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute successfully designed a revolutionary, high-throughput, robotic platform that automates and standardizes the process of transforming patient samples into stem cells. This unique platform, the NYSCF Global Stem Cell Array, for the first time gives researchers the scale to look at diverse populations to better understand the underlying causes of disease and create new individually tailored treatments, enabling precision medicine in patient care. A paper published in Nature Methods demonstrates how this novel, highly efficient technology automates the entire process of generating patient-specific stem cells while reducing variability resulting from manual manipulations.”

Till & McCulloch meetings

World Stem Cell Summit & RegMed Capital Conference update:
Join us in Atlanta December 10-13. Early-bird registration rates now apply. Register now!

Recently confirmed speakers:

Karen S. Aboody, MD
Department of Neurosciences and Division of Neurosurgery
City of Hope National Medical Center & Beckman Research Institute

Martin Grumet, PhD
Associate Director W.M. Keck Center for Collaborative Neuroscience
Director Rutgers Stem Cell Research Center
Professor Cell Biology & Neuroscience
Rutgers University

Todd C. McDevitt, PhD
Senior Investigator Gladstone Institute of Cardiovascular Disease
Professor, Dept. of Bioengineering & Therapeutic Sciences, UCSF

Healthcanal: Are We Really on the Road to a Cure for HIV/AIDS?
Kevin McCormack reports that the California Institute for Regenerative Medicine (CIRM) joined with the AIDS Project Los Angeles to hold a Town Hall event in West Hollywood called “HIV Matters: Countdown to a Cure: California Leads the Way.” Nearly 120 people showed up to listen to stem cell scientists from USC, City of Hope, Calimmune and Sangamo Biosciences — all of whom are using CIRM funding to develop new treatments and hopefully even cures for HIV/AIDS. The article provides details on the progress of these funding initiatives.

The San Diego Union-Tribune: Embryonic Cell Power Increased. Totipotent Cells Could Create Entire Organism on Their Own
“Totipotent stem cells apparently can be generated from pluripotent embryonic stem cells by altering how chromatin and histones are formed. Working with mouse embryonic stem cells, the researchers studied how to produce cells resembling embryos at the 2-cell stage, when they are still totipotent, capable of creating every cell in the body.” The research was published in Cell Reports.

360 Editor’s comment: We can count on ace Union-Tribune journalist Bradley Fikes to get to the heart of a story. Researchers at INSERM and the Max Planck can now induce totipotent cells in mice! What are the ethical implications when applied to humans? Even though first in mice, this new research seems underreported.

Life Interrupted

Eureka Alert: Scientists Create Functional Liver Cells from Stem Cells-Major Implications for Liver Biology and Drug Discovery
In research published in Hepatology, scientists from the Hebrew University of Jerusalem's Alexander Grass Center for Bioengineering report that they produced large amounts of functional liver cells from human embryonic and genetic engineered stem cells. Quoted in the media release is Prof. Oren Shibolet, Head of the Liver Unit at the Tel-Aviv Sourasky Medical Center, who was not involved in this study. "The implications for liver biology and drug discovery are quite staggering. The method provides access to unlimited amounts of functional liver cells and is likely to critically improve our ability to predict drug toxicity, which was previously limited by the unavailability of liver cells.”


New Scientist: Mutation Alert Halts Stem Cell Trial to Cure Blindness
"A pioneering stem-cell trial has been halted after genetic mutations were discovered in the cells of a participant. One of the mutations may carry a remote risk of cancer. The RIKEN clinical trial is the first to explore whether cells known as induced pluripotent stem (iPS) cells can be used to treat disease."


LEXOLOGY: Expert Group Publishes Recommendations on UK Regenerative Medicines
“An expert group of doctors, academics, pharmaceutical company representatives and government officials has recently published a report (‘Building on our own potential: a UK pathway for regenerative medicine’) affirming the UK’s ambition to become a leader in the research, manufacture and clinical use of regenerative medicine. The report also identified recommendations for further streamlining the regulation of the development of regenerative medicines, and developing an EU-wide consensus on the correct application of the EU regulatory framework.” To download the full report click here.


PHYS.ORG: Scientists Discover Molecular Cell Cycle Clock that Controls Stem Cell Potency
“Singapore scientists from A*STAR's Genome Institute of Singapore (GIS) have, for the first time, found further evidence of how the differentiation of pluripotent cells is tied to and controlled by the cell cycle clock. This deeper understanding of how cells become differentiated is extremely important when considering therapeutic potentials.”

Join MSC Experts at MSC 2015 in Cleveland- Aug 17-19! See Dr. Arnold Caplan’s video invitation:

Army Technology Magazine: Innovative Treatments Offer Hope for Burn Victims
According to the director of the Armed Forces Institute for Regenerative Medicine (AFIRM), Kristy Pottol, "Regenerative medicine is a rapidly growing area of science that aims to unlock the body's own ability to rebuild, restore or replace damaged tissue and organs. Much of regenerative medicine research in the civilian sector is focused on finding ways to reduce the burdens of chronic illness - diabetes, heart disease and others. The US Department of Defense wants to use these technologies to treat complex traumatic injuries."

UGA Today: University of Georgia’s Regenerative Bioscience Center Collaborates in Development of Brain-Friendly Interfaces
“Recent research published in the journal Microsystems & Nanoengineering could eventually change the way people living with prosthetics and spinal cord injury lead their lives. Instead of using neural prosthetic devices—which suffer from immune-system rejection and are believed to fail due to a material and mechanical mismatch—a multi-institutional team, including the University of Georgia's Regenerative Bioscience Center, Georgia Tech, Emory and the University of Pennsylvania developed a brain-friendly extracellular matrix environment of neuronal cells that contain very little foreign material. These by-design electrodes are shielded by a covering that the brain recognizes as part of its own composition.”


Marketplace Tech: Drug Made with 3-D Printer Wins First FDA Approval
“For the first time, the Food and Drug Administration (FDA) has given approval for a 3-D-printed epilepsy drug meant to help people control their seizures. The active ingredient in the SPRITAM isn’t new, but what is new is the method Aprecia Pharmaceuticals used to make it, according to the company. The company says its process for printing the drug makes the pill smaller and faster dissolving. That pleases Janice Buelow, a longtime nurse and vice president at the Epilepsy Foundation, who’s seen her patients struggle with their current medicines.” 360 Editor's Comment: Future shock!

The Guardian: Scientists in Iran Clone Endangered Mouflon – Born to Domestic Sheep
A domestic sheep has given birth to a baby mouflon in a rare successful example of interspecies cloning, according to scientists in Iran. The wild Isfahan mouflon was cloned at Iran’s Royan Institute, using the domestic sheep as a surrogate mother. “Poaching has driven the Isfahan mouflon close to extinction in Iran. The cloned mouflon, which looks similar to a deer, has been named Maral, a Persian name for a reindeer and for new babies, which means svelte.”

360 Editor’s Comment: “Maral” joins the pantheon of some famous named cloned animals, among them: “Dolly” (sheep),” Snuppy” (dog),”Daisy” (heifer), “CC”(cat) and “Tiny” (the iPS cloned mouse).

360 Newsletter Editor

Bernard Siegel
Executive Director
Genetics Policy Institute

Stem Cells and the Transformative Power of Hope-a TEDx talk by Bernard Siegel, Editor of 360 Newsletter

About GPI

The nonprofit Genetics Policy Institute (GPI) seeks to establish a positive policy, regulatory and societal framework to enable research to flourish, under the highest ethical and medical standards. We seek to accelerate the discovery and development of lifesaving cures and therapies to alleviate human suffering due to chronic and terminal afflictions. Visit Website.

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Genetics Policy Institute (GPI) and the Regenerative Medicine Foundation (RMF) Announce Merger Plan

Domain: Medical
Category: Biology

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