360 Stem Cell & Regenerative Medicine Newsletter- June 04, 2015

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360 Stem Cell & Regenerative Medicine Newsletter - June 4, 2015

Featured Video from World Risk and Insurance News: Dr. Aubrey de Grey discusses regenerative medicine and implications on longevity, society and insurance industry

Regenerative Medicine May Eliminate Alzheimer’s, Heart Disease and Cancer, and Impact Pensions and Insurance
In our first 360 featured video, WRIN.tv speaks with Dr. Aubrey de Grey during the 2015 European Insurance Forum. "He is a biomedical gerontologist and Chief Science Officer at the SENS Research Foundation, and discusses the latest in regenerative medicine and what longer life expectancy means to the insurance industry. Dr. de Grey says regenerative medicine refers to stem cell therapy and tissue engineering, or the creation of artificial organs. It includes “repairing the molecular and cellular structure of the body.” Within regenerative medicine, stem cell research is the most advanced, with many areas in critical trial, including treatments for macular degeneration or Parkinson’s disease. Other research is the beginning stages of development, but progress is very encouraging."

World Stem Cell Summit

Featured video from Mayo Clinic: Mayo Clinic Advanced Product Incubator (API)

"The Center for Regenerative Medicine has launched state-of-the-art platforms for the express purpose of translating new knowledge into tailored regenerative solutions. The Advanced Product Incubator (API) aims to establish cell-free platforms to develop safe and effective regenerative therapies. The API infrastructure participates in the manufacturing of a spectrum of clinically relevant therapies spanning from devices to biological and pharmaceutical agents. Built according to Current Good Manufacturing Practices (CGMP), this multidisciplinary, first-of-its-kind facility bridges teams of researchers and physicians with scientific and industry experts to accelerate product development. The API design fosters the translation of laboratory discoveries into clinical grade curative products developed with the lowest possible risk to patients."

360 Editor’s Note: Learn more about Mayo Clinic’s futuristic vision in a very readable article in Fast Company titled “The $6.5Billion, 20- Year Plan to Transform an American City – Rochester, Minnesota”

The Washington Post: How Scientists Built the World’s First Lab-Grown Limbs
“Harald Ott, a researcher and thoracic surgeon at Massachusetts General Hospital, is the proud parent of the world’s first lab-grown biolimb — a living, functioning, artificial leg that responds to stimuli and even circulates blood, the hospital Though it’s still a long way off from made-to-order transplants for humans, Ott and other regeneration experts say that the tiny pink rat leg is a step toward the future of artificial limbs.” To read the MGH media release, Click here.

Wake Forest

Science Insider AAAS: Karolinska Releases English Translation of Misconduct Report on Trachea Surgeon
“The investigator, Bengt Gerdin, professor emeritus of surgery at Uppsala University, examined six papers about the patients and one on animal tests of the procedure and found multiple problems that he deemed serious enough to constitute misconduct, including inaccurate descriptions of the condition of patients at the time of publication and stating that ethical permission had been obtained for the work although there is none on record. The report, submitted to the Karolinska vice chancellor, concludes that Macchiarini ‘bears the main responsibility for the publication of false or incomplete information in several papers, and is therefore guilty of scientific misconduct.’ Macchiarini has disputed the allegations.”

Icems

Iceland Review Online: Trachea Implants Investigated, Icelandic Doctors Involved
The deepening Paolo Macchiarini investigation is becoming even more unsettling when one ponders the Icelandic connections. The 360 Newsletter “investigation team” came across these items from an online source. Read the entire article and draw your own conclusions. “Icelandic surgeon Tómas Guðbjartsson took part in one of the operations and Karolinska was under the directorship of Birgir Jakobsson, the current Chief Medical Officer of Iceland, at the time of the operations. Four out of Macchiarini’s eight patients have died since receiving synthetic tracheas, including his first patient, Andemariam Teklesenbet Beyene from Eritrea, who was a PhD student of geology at the University of Iceland at the time of his operation in June 2011.”

The Alliance for Regenerative Medicine Issues Position Statement Regarding Human Embryo Germline Genome Editing
"The Alliance for Regenerative Medicine (ARM), the international organization representing the regenerative medicine and advanced therapies community, released its position statement regarding human germline modification. ARM’s position is that it is neither appropriate nor acceptable to pursue this kind of research at this time, given the highly premature stage of germline modification technology and the many scientific and ethical issues that surround it. The statement emphasizes that this field of research is controversial and its impact on future generations, both long- and short-term, remain unproven. In the statement, ARM calls for a voluntary moratorium to provide an opportunity for dialogue within the wider scientific community, to examine the safety and ethical implications of this technology’s use on the human germline. ARM had previously articulated a number of these points in its March 2015 commentary piece in Nature."

wiley

Nature: CRISPR, the Disruptor-
A Powerful Gene-editing Technology is the Biggest Game Changer to Hit Biology Since PCR. But with its Huge Potential Come Pressing Concerns

360 comment: This insightful article from Nature describes the emergence of “CRISPR-the Disruptor” (sounds like a new “Marvel” character) and the implications for science and the world. “CRISPR- the Disruptor” is a force surely to be reckoned with and potential nemesis to “Zinc Fingers” everywhere.

Biobridge

Arizona State University (ASU) Researchers Taking Bold Steps Toward Engineering New Lungs
“ASU researchers are working to improve aspects of lung engineering that may in the future contribute to providing a nearly limitless supply of donor organs, ideally matched to their recipients, or to repairing damaged lungs. In work appearing in the advanced online edition of the journal PLOS ONE, the researchers describe an elegant method to improve aspects of lung engineering that may in the future contribute to providing a nearly limitless supply of donor organs, ideally matched to their recipients, or to repairing damaged lungs. Although years of work and further study remain before such research could be a reality in the clinic, the potential is there and the results in animal studies are promising.”

Wake Forest

Azrieli Foundation Donates $10M for Research at the Hebrew University for Stem Cells & Genomics
“The Azrieli Foundation, one of Canada's largest foundations, has donated $10 million to fund innovative research at the Hebrew University of Jerusalem's newly inaugurated Azrieli Center for Stem Cells and Genetic Research. The funds will also support Israeli doctoral students and young research faculty, and Canadian post-doctoral students. Led by Dr. Nissim Benvenisty, one of the world's leading stem cell pioneers, working in collaboration with laboratories in Boston, New York and Los Angeles, the new centre will be home to one of the largest repositories of stem cells carrying genetic diseases and chromosomal disorders in the world. Focusing on modeling human diseases without the use of animals, the centre will study Down syndrome, Prader-Willi syndrome, hereditary diabetes, and will pay special attention to Fragile X syndrome, a genetic condition that causes intellectual disability and behavioural challenges, and is linked to autism in boys. Researchers will focus on developing novel therapies to treat these diseases.”

New York Magazine: The Gordie Howe Protocol
“His family believes a controversial stem-cell treatment brought the hockey legend back from the dead. But they can’t agree on how much of their father belongs to a public who still wants a piece of him.”

PharmaBiz.com: NIH-funded Study Provides New Platform for Testing Treatments for Neurodegenerative Disorders
“Scientists at Mayo Clinic, Jacksonville, Florida created a novel mouse that exhibits the symptoms and neurodegeneration associated with the most common genetic forms of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), both of which are caused by a mutation in the a gene called C9ORF72. The study was partially funded by the National Institutes of Health and published in the journal Science.”

360 Newsletter Editor


Bernard Siegel
Executive Director
Genetics Policy Institute





Stem Cells and the Transformative Power of Hope-a TEDx talk by Bernard Siegel, Editor of 360 Newsletter

About GPI


The nonprofit Genetics Policy Institute (GPI) seeks to establish a positive policy, regulatory and societal framework to enable research to flourish, under the highest ethical and medical standards. We seek to accelerate the discovery and development of lifesaving cures and therapies to alleviate human suffering due to chronic and terminal afflictions. Visit Website.

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Category: Biology
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