360 Stem Cell & Regenerative Medicine Newsletter- March 12, 2015

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360 Stem Cell & Regenerative Medicine Newsletter - March 12, 2015

Featured Video : Debate in Oklahoma Legislature on HB 1379

Editor’s comment: This debate is absolutely fascinating as lawmakers overwhelmingly pass an “emergency” bill that would subject scientists performing human embryonic stem cell research to a fine and imprisonment. This type of legislation sends a chill to all those believing in freedom of scientific inquiry. Couples donating embryos for research purposes would also be condemned to imprisonment. In the course of the debate, the bill’s author admits that the legislation is a “first step” and implies that IVF practices might become a future target.
Oklahoma House passes ban on embryonic stem cell research…again
According to the AP, the Oklahoma House passed emergency legislation criminalizing embryonic stem cell research in the state. “House members voted 80-13 for the Measure Monday and sent it to the Senate for consideration. The measure by Republican Rep. Dan Fisher of El Reno would make it a crime to perform embryonic stem cell research in Oklahoma. The bill is opposed by many doctors and business groups, who argue it could impede scientific research in Oklahoma.” Read the full bill and legislative history here.
Johns Hopkins researchers engineer custom blood cells. Step toward new treatment for patients with sickle cell disease
"Johns Hopkins Medicine reports that researchers have successfully corrected a genetic error in stem cells from patients with sickle cell disease, and then used those cells to grow mature red blood cells. The researchers maintain that the study represents an important step toward more effectively treating certain patients with sickle cell disease who need frequent blood transfusions and currently have few options.” The results appear in an upcoming issue of the journal Stem Cells.
World Stem Cell Summit
Asian Scientist Magazine: How many times can cells be re-programmed? Induced pluripotent stem cells can be used to generate up to six generations of mice but accumulate harmful mutations over time.
“Scientists have shown that mice generated from induced pluripotent stem (iPS) cells and tetraploid blastocyst complementation can tolerate the accumulation of somatic mutations for up to six generations. However, their work published in Nature Communications also showed that subsequent generations of all-iPS mice had fewer pups born alive. This study provides information to better understand the association between gene mutations and developmental effect, essential knowledge for screening pre-clinical bio-safety of iPS cells.” The research team was led by Professor Cai Jun from the Beijing Institute of Genomics of the Chinese Academy of Sciences.
Canada and Japan leading innovation in regenerative medicine; two nations, different strategies, one goal: Addressing incurable medical conditions
The Canada-based company RepliCel issued an informative media release focusing on how Japan and Canada (through CCRM) are supporting the commercialization of regenerative medicine. “RepliCel ranks as one of the few foreign cell therapy companies with a Japanese partner, and one of an even smaller group with an active manufacturing footprint in Japan.”
Wake Forest
Scripps Research, Mayo Clinic scientists find class of drugs that boosts healthy lifespan in mice. What are human implications?
According to a Scripps media release, “a research team from The Scripps Research Institute (TSRI), Mayo Clinic and other institutions has identified a new class of drugs that in animal models dramatically slows the aging process--alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan. Using transcript analysis, the researchers found that, like cancer cells, senescent cells have increased expression of ‘pro-survival networks’ that help them resist apoptosis or programmed cell death. This finding provided key criteria to search for potential drug candidates.” The new research was published online ahead of print by the journal Aging Cell.
Mayo Clinic
Oakland Press: Stem cell research at Oakland University (Michigan) may lead to easing pain, saving sight
OU’s William Beaumont Institute for Stem Cell and Regenerative Medicine is working to help make a reality the advent of stem cell cures for a multitude of illnesses and conditions. The Institute was launched at the World Stem Cell Summit held in Detroit, Michigan in 2010.

“The state of Ohio saw another first in orthopaedic surgery when Dr. David Flanigan of the OSU Wexner Medical Center used a NeoCart tissue implant, made from a patient’s own cells, to treat knee cartilage damage last week. The surgery, which occurred March 3, is one way to treat knee cartilage damage or injuries, which are common in athletes, but also affect the general populace as wear occurs over time, Flanigan said, adding that he is hopeful this new surgery could provide a different alternative for patients.” The surgery utilizes a product created by the regenerative medicine company Histogenics.
From Georgia: ArunA Biomedical and neuromics announce strategic sales agreement
According to ArunA Biomedical CSO, Steven Stice,"The Neuromics sales partnership will integrate into a unified product portfolio a one-stop neural research shop that offers a unique value proposition to our customers. Neuromics array of reagents coupled with ArunA Biomedical’s neural stem cell development expertise and ability to translate neural cells into reliable models for cell based assays enables neuroscientists access to proven tools and expertise not found elsewhere.”
Chicago Sun-Times: Northwestern gets $117.8 million gift; will go mostly toward regenerative medicine
“Northwestern University alumnus and board member Louis A. Simpson and his wife, Kimberly K. Querrey, have donated $117.75 million to the university’s cutting-edge research in bio-nanotechnology and regenerative medicine.”

360 Newsletter Editor

Bernard Siegel
Executive Director
Genetics Policy Institute

Stem Cells and the Transformative Power of Hope-a TEDx talk by Bernard Siegel, Editor of 360 Newsletter
Domain: Medical
Category: Biology

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