360 Stem Cell & Regenerative Medicine Newsletter - Sept 9, 2014

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360 Stem Cell & Regenerative Medicine Newsletter - Sept 9, 2014

Featured video: Saving teeth with stem cells
Whole organ 'grown' inside animal for the first time
Dr. Anibal Diogenes, a pioneer in endodontic regenerative research at the University of Texas Health Science Center at San Antonio and WSCS14 speaker, explains the promising research utilizing stem cells to regenerate teeth. The Health Science Center is playing a major role in this research. Dr. Diogenes led the first clinical study that proved children’s oral stem cells could regenerate their teeth. The discovery led to Health Science Center researchers contributing to the definition of the term “regenerative endodontics” and the national guidelines for dental practitioners. Read more about this exciting research.
Washington Post: $1 million prize offered in scientific contest to find fountain of youth
Joon Yun, who heads a California venture fund, has enlisted nearly a dozen teams of scientists in a 21st century hunt described as “the fountain of youth.” The Palo Alto Longevity Prize will provide $1 million cash prize for the winners. Among the institutions who have accepted the challenge are George Washington University’s Department of Pharmacology and Physiology; a team from Charité University School of Medicine in Berlin, Germany, which will focus on gene modification; a group from Albert Einstein College of Medicine in New York, which will look at hypothalamic regulation; and a team from the Texas Heart Institute in Houston that will examine the role of stem cells in aging. Dr. Doris Taylor of the Texas Heart Institute says, “We believe that aging is both a failure of stem cell number and stem cell function. It’s really not that complicated: replace stem cell number, replace stem cell function, prolong life.”
European Lung Foundation: Study sheds light on how stem cells can be used to treat lung
A new study has revealed how stem cells work to improve lung function in acute respiratory distress syndrome (ARDS), a life-threatening condition in which the efficiency of the lungs is severely reduced. Dr Anna Krasnodembskaya, lead author of the study from the Queens University Belfast, said: “This is the first study to our knowledge that has looked at how stem cells can change the functional properties of the macrophages in both humans and a mouse model. The findings highlight the advantages of stem cell treatment, as they can actively respond to the local micro-environment and exert multiple beneficial effects. We believe that clinical trials are now needed to test whether this can be an effective treatment for people suffering from ARDS.”
Ottawa Citizen: Canadian research offers hints at muscle growth for elderly
Dr. Michael Rudnicki of the University of Ottawa and Scientific Director of the Stem Cell Network has discovered that a chemical signaling pathway is making it more difficult for muscle cells to multiply and rebuild. The pathway becomes more active as we age, sending signals that prevent muscles from rebuilding as well as they did at a younger age. The research was published in the journal Nature Medicine.
University of Miami: Collaborative study finds new approach for treating esophageal cancer
“Drawing on their clinical and scientific experience, researchers at the University of Miami Miller School of Medicine have identified a new strategy for attacking esophageal adenocarcinoma (EAC), one of the most deadly forms of cancer. Their study found that inhibiting one of the key cellular signaling pathways might result in a better response to chemotherapy, with a potential improvement in patient outcomes.” The study was published online in the American Association for Cancer Research (AACR)‘s journal, Cancer Research.
Yale News: How to tell good stem cells from the bad- researchers answer key question
The promise of embryonic stem cell research has been thwarted by an inability to answer a simple question: How do you know a good stem cell from a bad one? Yale researchers reported in the journal Cell Stem Cell that they have found a marker that predicts which batch of personalized stem cells will develop into a variety of tissue types and which will develop into unusable placental or tumor-like tissues.
REMEDI (Ireland): Irish team in cornea transplant breakthrough using MSC’s
“Cornea transplantation, known as keratoplasty, is the most widely used treatment for this disease. During the procedure, scarred or diseased corneal tissue is removed and replaced with healthy tissue from an organ donor. In 30% of these operations, the transplant fails as a result of rejection by the patient's own immune system. However, researchers at NUI Galway are using adult stem cells to fight against this type of rejection. Their work suggests that by administering a specific type of stem cell - mesenchymal stem cells or MSCs - transplant rejection rates could fall to as low as 10%.” Details of the findings were published in the American Journal of Transplantation.
Wake Forest Baptist Medical Center: Milestone reached in work to build replacement kidneys in the lab
According to a media release, regenerative medicine researchers at Wake Forest Baptist Medical Center have addressed a major challenge in the quest to build replacement kidneys in the lab. Working with human-sized pig kidneys, the scientists developed the most successful method to date to keep blood vessels in the new organs open and flowing with blood. “If proven successful, the new method to more effectively coat the vessels with cells (endothelial) that keep blood flowing smoothly, could potentially be applied to other complex organs that scientists are working to engineer, including the liver and pancreas.” The work is reported in journal Technology

360 Newsletter Editor

Bernard Siegel
Executive Director
Genetics Policy Institute

Stem Cells and the Transformative Power of Hope-a TEDx talk by Bernard Siegel, Editor of 360 Newsletter

About GPI

The nonprofit Genetics Policy Institute (GPI) seeks to establish a positive policy, regulatory and societal framework to enable research to flourish, under the highest ethical and medical standards. We seek to accelerate the discovery and development of lifesaving cures and therapies to alleviate human suffering due to chronic and terminal afflictions. Visit Website.

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Domain: Medical
Category: Biology

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