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Genome-wide Acetylation in Heat-shocked Cells

 Sabrina Fritah, Edwige Col, Cyril Boyault, Jerome Govin, Karin Sadoul, Susanna Chiocca, Elisabe
Description: A major regulatory function has been evidenced here for HSF1, the key transcription factor of the heat-shock response, in a large-scale remodeling of the cell epigenome. This work identifies HSF1 as a master regulator of global chromatin acetylation and reveals a cross-talk between HSF1 and histone deacetylases in the general control of genome organization in response to heat shock.
Views: 2124
Domain: Medical
Category: Biology
Molecular Biology of the Cell Vol. 20, 4976 � 4984, December 1, 2009

Heat-Shock Factor 1 Controls Genome-wide Acetylation in Heat-shocked Cells
Sabrina Fritah,* Edwige Col,* Cyril Boyault,* Jerome Govin,* Karin Sadoul,* � ^ Susanna Chiocca, Elisabeth Christians, Saadi Khochbin,* Caroline Jolly,* and Claire Vourc'h*
*Institut National de la Sante et de la Recherche Medicale ... See more

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