Go to Page # Page of 24
loading

Large Animal Models of Orthopedic Injury

 John Peroni
  27th-May-2016
Description: Objectives of large animal modeling: A. Assessment of the predictive value of preclinical models for clinical efficacy. B. Mimic wound healing environment in a challenging clinical settings: large bone and soft tissue defects, sites of prior surgery. C. Macroscopic similarities to people: Weight bearing and biomechanics closer to human subjects. D. Microscopic similarities are in question: Canine possibly the closest. Where and how: Contract laboratories- Protocol driven, Efficient, Expensive. Institutional laboratories- Intellectual contribution to model and study development, Vested interest from local PI, Ancillary expertise, Time consuming, Excessive overhead costs.
Views: 7847
Domain: Medical
Category: Veterinary
Contributing Organization: World Stem Cell Summit
 ‐ More of their Presentations
SEMICONDUCTOR ANALYTICS
Contents:
Large animal models of orthopedic
injury
JOHN PERONI

Introduction
• Why large animal models
• Where and How
• Bone

– Osteotomy and non-osteotomy models

• Tendon/ligment

– Mechanical injury
– Chemical injury

• Naturally occurring models
• Cartilage

– Intact joint cartilage defects
– Osteoarthritis modeling

Translation from rodent ... See more

Recent Presentations

Yalin Firinci
19 August, 2019

Regulatory Science for R&D Promotion

At present, the nation’s policy for Research and Development (R&D) promotion of innovative pharmaceuticals & improvement of environments for the R&D is formulated by Japanese gover

...
18 August, 2019
...
16 August, 2019