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Learning from Mother Nature: Innovative Tools to Boose Endogenous Repair of Critical or Difficult-to-Heal Large Tissue Defects

 Ranieri Cancedda, Sveva Bollini, Fiorella Descalzi, Maddalena Mastrogiacomo, Roberta Tasso
Description: Over the last two decades, significant progresses have been made by transplantation of “ex vivo” expanded autologous stem/progenitor cells, mostly associated with biomaterials, for the repair of chronic or difficult-to-heal tissue lesions and defects caused by disease, trauma, or tumor surgery. Our lab was among the pioneers in applying a tissue engineering approach for repairing and reconstructing human epithelia in burned patients (De Luca et al., 1989), as well as urethra for congenital malformations (Romagnoli et al., 1990), corneal epithelium in eye chemical burns (Pellegrini et al., 1997), and long-bone defects in trauma outcome (Quarto et al., 2001). However, despite these successes, we must acknowledge that major constraints exist for the broad application of this approach.
Views: 1493
Domain: Medical
Category: Biology
Contributing Organization: Frontiers Media S.A.
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published: 28 April 2017
doi: 10.3389/fbioe.2017.00028

Learning from Mother Nature:
innovative Tools to Boost
endogenous Repair of Critical
or Difficult-to-Heal Large Tissue
Ranieri Cancedda1,2*, Sveva Bollini 2, Fiorella Descalzi 1, Maddalena Mastrogiacomo 2 and
Roberta Tasso3
 Biorigen Srl, Genova, Italy, 2 Department of Experimental Medicine, University of Genova, ... See more

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