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Large Animal Models of Orthopedic Injury

 John Peroni
Description: Objectives of large animal modeling: A. Assessment of the predictive value of preclinical models for clinical efficacy. B. Mimic wound healing environment in a challenging clinical settings: large bone and soft tissue defects, sites of prior surgery. C. Macroscopic similarities to people: Weight bearing and biomechanics closer to human subjects. D. Microscopic similarities are in question: Canine possibly the closest. Where and how: Contract laboratories- Protocol driven, Efficient, Expensive. Institutional laboratories- Intellectual contribution to model and study development, Vested interest from local PI, Ancillary expertise, Time consuming, Excessive overhead costs.
Views: 1789
Domain: Medical
Category: Veterinary
Contributing Organization: World Stem Cell Summit
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Large animal models of orthopedic

• Why large animal models
• Where and How
• Bone

– Osteotomy and non-osteotomy models

• Tendon/ligment

– Mechanical injury
– Chemical injury

• Naturally occurring models
• Cartilage

– Intact joint cartilage defects
– Osteoarthritis modeling

Translation from rodent ... See more

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