Description: Objectives of large animal modeling: A. Assessment of the predictive value of preclinical models for clinical efficacy. B.
Mimic wound healing environment in a challenging clinical settings: large bone and soft tissue defects, sites of prior surgery. C. Macroscopic similarities to people: Weight bearing and biomechanics closer to human subjects.
D. Microscopic similarities are in question: Canine possibly the closest. Where and how: Contract laboratories- Protocol driven, Efficient, Expensive.
Institutional laboratories- Intellectual contribution to model and study development, Vested interest from local PI, Ancillary expertise, Time consuming, Excessive overhead costs.