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Ebola Virus Infection in Dogs and Pigs

 James A. Roth DVM PhD
Description: Ebola Virus Antibody Prevalence in Dogs and Human Risk: Serologic survey of dogs in highly infected areas during 2001-2002 Ebola Zaire outbreak in Gabon. Symptoms were not observed in any of these dogs. Blood samples were negative by PCR. “Although dogs can be asymptomatically infected, they may excrete infectious viral particles in urine feces and saliva for a short period before virus clearance, as observed experimentally in other animals.” Discovery of Swine as a Host for the Reston ebolavirus: Swine serum and tissue samples from Philippines submitted to FADDL in 2008 . Highly pathogenic PRRS virus and PCV2 isolated . Cytopathic virus also isolated in VERO cells (non-permissive to PRRSV) . Microarray revealed Reston Ebola . Reston Ebola was found only in samples also positive for PRRSV . Genomes of three virus isolates were significantly divergent from each other, suggesting that they have been circulating for several years . Ebola Reston Virus Infection of Pigs: Clinical Significance and Transmission Potential: Experimental challenge with REBOV in 16 five week old pigs . Replication of virus in internal organs and viral shedding from nasopharynx and feces in absence of clinical signs . Virus present in skeletal muscle . Concurrent respiratory infection may facilitate transmission . “...asymptomatic infection of pigs with REBOV occurs ... animals so affected pose a transmission risk to farm, veterinary, and abattoir workers.”
Views: 5816
Domain: Medical
Category: Veterinary
Contributing Organization: AAVLD
 ‐ More of their Presentations

Ebola Virus Infection
in Dogs and Pigs
James A. Roth, DVM, PhD
Center for Food Security and Public
College of Veterinary Medicine
Iowa State University

Five Species of Ebola Viruses
Enveloped RNA virus related to
Marburg virus
• Genus: Ebolavirus (5 species)

− Pathogenic

for humans (Africa)

Zaire ebolavirus (ZEBOV)
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