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Plant Medicine and Veterinary Potential of Antimicrobial Peptides Produced by Entomopathogenic Nematode Symbiotic Bacteria

 András Fodor, J. Racsko, J. Hogan, D. Vozik
Description: INTRODUCTION- Antibiotics-resistance of pathogenic organisms emerged as a new challenge to plant protection, veterinary and even human clinical practice. The antibiotic multidrug-resistance can be overcome by anti-microbial compounds of totally different mode of action. Biocontrol potential of antimicrobial peptides produced by EPB), Xenorhabdus budapestensis (EMA) and X. szentirmaii (EMC) is discussed in this presentation. This EPN bacterium (EPNB) is carried into the blood cavity (hemocoel) of insect hosts by a specific transmission (infective dauer juvenile, IJ) stage of the nematode. These bacteria could easily be isolated and cultured in the laboratory both in solid and liquid media, both in small and larger scale and test for antagonistic antimicrobial actibities. EPNB ON LBTA INDICATOR PLATES- Once there, the nematode releases the bacteria, which then express immune suppressive and virulence factors that kill insects. Then, within the insect cadaver, bacterial activity promotes degradation of insect tissues and deters competitors (including opportunistic non-host nematodes). Thus, as part of their lifecycle, EPNB obligatorily interact with and influence the physiologies of competing micro-organisms, nematode parasites, and insects, largely through the production of bioactive proteins and small molecules. MATERIALS AND METHODS- After detaliled comparison of EPNB species, strains and isolates from the aspect of their antagonistic activity toward different test tarhets, we found that two species, Xenorhabdus budapestensis and X. szentirmaii have outstandind antimicrobial potential. MATRIALS: Antimicrobial producers and test organisms- This study focuses mainly on the bacterium Xenorhabdus budapestensis which is the obligate symbiont of the EPN Steinernema bicornutum and pathogen of insects. Some data on X. szentirmaii, a strain which had already been sequenced are also presented.
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Domain: Medical
Category: Veterinary
Contributing Organization: OMICS Group Conferences
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Semiconductor Analytics
Plant medicine and veterinary
potential of antimicrobial peptides
produced by entomopathogenic
nematode symbiotic bacteria
András Fodor1
J. Racsko1, J. Hogan1, D. Vozik2
L. Makrai3, F., Olasz4,
H. Goodrich Blair5
Fodor et al., BABE_2014


• Antibiotics-resistance of pathogenic organisms
emerged as a new challenge to plant protection,
veterinary and even human clinical p ... See more

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