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Cancer genomics & precision medicine in the 21st century

 Lee J. Helman MD
Description: Single Nucleotide Polymorphisms (SNP): Variation in single base in DNA in germline, most common variants in genome (over 50 million identified), SNP arrays interrogate the entire genome -uses DNA from germ-line (blood). Used in Genome Wide Association Studies (GWAS): Typically uses SNP arrays to compare populations (with disease or not), Determines risk or susceptibility to some state. Cancer is a disease of the genome (cont): Driver mutations are the mutations we would like to target and inhibit their function.
Views: 985
Domain: Medical
Category: Therapy
Maxims of Tech: Rules of Engagement for a Fast Changing Environment
Cancer Genomics & Precision Medicine
in the 21st Century
Lee J. Helman, MD Scientific Director for Clinical Research

• Define terms
• Describe vision for how genetic
characterization of tumors will change
treatment paradigms for cancer in the
• Describe ongoing clinical trials currently
using this approach
• Describe potential difficulties/pitfalls

T ... See more

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