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Why Are Celiac Disease and Gluten Sensitivity on a Rise?

 Alessio Fasano M.D.
Description: All disease begins in the gut - Hippocrates 460 BC. The gut is not like Las Vegas: what happens in the gut does not stay in the gut – A.F. 2010 AC. The intestinal mucosa is the battlefield on which friends and foes need to be recognized and properly managed to find the ideal balance between tolerance and immune response. Celiac disease as the ideal paradigm to study how friends can become foes. Celiac Disease as a Unique Model of Autoimmunity: The only autoimmune disease in which specific MHC class II HLA (DQ2 and/or DQ8) are present in >95% of patients; The auto-antigen (tissue Transglutaminase) is known; The environmental trigger (gluten) is known; Elimination of the environmental trigger leads to a complete resolution of the autoimmune process that can be re-ignited following re-exposure to gluten.
Views: 1279
Domain: Medical
Category: Therapy
Why Are Celiac Disease and
Gluten Sensitivity on a Rise?

Alessio Fasano, M.D.
Mucosal Immunology and Biology Research Center
And Center for Celiac Research
Massachusetts General Hospital, Boston MA – U.S.A.

Lecture Objectives
Gluten + Genes = Celiac Disease
Not So Fast!


Clinic Outcome

All disease begins in the gut Hippocrates 460 BC
The gut is not lik ... See more

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