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Parkinson Disease: Pathophysiology, Diagnosis, DaTscan & Differential Diagnosis

 Maureen A. Leehey M.D.
Description: Main Biochemical Abnormality: Marked striatal DA depletion, ~70% DA loss for symptom manifestations. α‐synuclein PD pathophysiology- Aggregated protein may : Form pores in cell membrane, Interfere with axonal transport, Impair proteasomal system, Interfere with chaperone role in autophagy, Selectively damage DA neurons. LRRK2: Leucine‐rich repeat kinase 2, AD, Most common cause of familial and sporadic PD- 1.5% of late‐onset PD,40% of Arab PD pts,20% of Ashkenazi Jewish PD pts, Late onset ‘idiopathic PD’ phenotype- Homozygous = heterozygous phenotype.
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Domain: Medical
Category: Therapy
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Parkinson Disease: 
Pathophysiology, Diagnosis, 
DaTscan & Differential Diagnosis 
Maureen A. Leehey, M.D.
Professor of Neurology
University of Colorado Denver

• Grants & research support
– Neurologix, Inc., Schwartz Biosciences, Impax

• Consu ... See more

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