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Rejection of Mouse Cardiac Allografts by Costimulation in trans

 DA Mandelbrot, K Kishimoto, H Auchincloss Jr, AH Sharpe and MH Sayegh
Views: 1872
Domain: Medical
Category: Therapy
Rejection of Mouse Cardiac Allografts by Costimulation in trans1
Didier A. Mandelbrot,2,3*� Koji Kishimoto,2 Hugh Auchincloss, Jr., Arlene H. Sharpe,4* and Mohamed H. Sayegh4
The activation of T cells by B7 costimulation in trans has been demonstrated in vitro, but the in vivo relevance is unknown. To study costimulation in trans of CD4 T cells in vivo, we performed cardiac transplants ... See more

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