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Targeting the Endothelin A Receptor to Inhibit Cyclooxygenase Expression in Ovarian Carcinoma Cells

 Francesca Spinella,1 Laura Rosano`, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, an
Description: New therapies against cancer are based on targeting cyclooxygenase (COX)-2. Activation of the endothelin A receptor (ETAR) by endothelin (ET)-1 is biologically relevant in several malignancies, including ovarian carcinoma. In this tumor, the ET-1/ETAR autocrine pathway promotes mitogenesis, apoptosis protection, invasion, and neoangiogenesis.
Views: 1894
Domain: Medical
Category: Biotech/Pharma
4670 Vol. 10, 4670 � 4679, July 15, 2004

Clinical Cancer Research

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Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells
Francesca Spinella,1 Laura Rosano,1 ` Valeriana Di Castro,1 Maria Rita Nicotra,3 Pier Giorgio Natali,2 and Anna Bagnato1
Laboratories of 1Molecular Pathology and Ultrastructure and ... See more

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