Go to Page # Page of 10
loading

Targeting the Endothelin A Receptor to Inhibit Cyclooxygenase Expression in Ovarian Carcinoma Cells

 Francesca Spinella,1 Laura Rosano`, Valeriana Di Castro, Maria Rita Nicotra, Pier Giorgio Natali, an
  10th-Dec-2008
Description: New therapies against cancer are based on targeting cyclooxygenase (COX)-2. Activation of the endothelin A receptor (ETAR) by endothelin (ET)-1 is biologically relevant in several malignancies, including ovarian carcinoma. In this tumor, the ET-1/ETAR autocrine pathway promotes mitogenesis, apoptosis protection, invasion, and neoangiogenesis.
Views: 1894
Domain: Medical
Category: Biotech/Pharma
Contents:
4670 Vol. 10, 4670 � 4679, July 15, 2004

Clinical Cancer Research

Featured Article

Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells
Francesca Spinella,1 Laura Rosano,1 ` Valeriana Di Castro,1 Maria Rita Nicotra,3 Pier Giorgio Natali,2 and Anna Bagnato1
Laboratories of 1Molecular Pathology and Ultrastructure and ... See more

Recent Presentations

...
23 August, 2019
...
22 August, 2019

What's Trust Have To Do With Compassion?

Trends of trust in healthcare. Trust needed for conversation between patients & physicians on overuse. Trust should be a core operating principle in health care.

...
21 August, 2019